EC 2.1.1.163 - Demethylmenaquinone methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.163

Names

Accepted name:
demethylmenaquinone methyltransferase
Other names:
S-adenosyl-L-methione—DMK methyltransferase
demethylmenaquinone C-methylase
2-heptaprenyl-1,4-naphthoquinone methyltransferase
2-demethylmenaquinone methyltransferase
S-adenosyl-L-methione:2-demethylmenaquinone methyltransferase
Systematic name:
S-adenosyl-L-methione:demethylmenaquinone methyltransferase

Reaction

Comments:

The enzyme catalyses the last step in menaquinone biosynthesis. It is able to accept substrates with varying polyprenyl side chain length (the chain length is determined by polyprenyl diphosphate synthase) [1]. The enzyme from Escherichia coli also catalyses the conversion of 2-methoxy-6-octaprenyl-1,4-benzoquinone to 5-methoxy-2-methyl-3-octaprenyl-1,4-benzoquinone during the biosynthesis of ubiquinone [4]. The enzyme probably acts on menaquinol rather than menaquinone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00911
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102094 , GO:0102955 , GO:0102027 , GO:0043770
UniProtKB/Swiss-Prot: (387) [show] [UniProt]

References

  1. Koike-Takeshita, A., Koyama, T., Ogura, K.
    Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus.
    J. Biol. Chem. 272 : 12380-12383 (1997). [PMID: 9139683]
  2. Wissenbach, U., Ternes, D., Unden, G.
    An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration.
    Arch. Microbiol. 158 : 68-73 (1992). [PMID: 1444716]
  3. Catala, F., Azerad, R., Lederer, E.
    Sur les propriétés de la desméthylménaquinone C-méthylase de Mycobacterium phlei
    Int. Z. Vitaminforsch. 40 : 363-373 (1970). [PMID: 5450997]
  4. Lee, P. T., Hsu, A. Y., Ha, H. T., Clarke, C. F.
    A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
    J. Bacteriol. 179 : 1748-1754 (1997). [PMID: 9045837]

[EC 2.1.1.163 created 2009]