EC - Sarcosine/dimethylglycine N-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
sarcosine/dimethylglycine N-methyltransferase
Other names:
sarcosine-dimethylglycine methyltransferase
sarcosine dimethylglycine N-methyltransferase
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase
Systematic name:
S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase [N,N-dimethylglycine(or betaine)-forming]



Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine [3]. The reactions are strongly inhibited by S-adenosyl-L-homocysteine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052729 , GO:0052730


  1. Nyyssölä, A., Kerovuo, J., Kaukinen, P., von Weymarn, N. and Reinikainen, T.
    Extreme halophiles synthesize betaine from glycine by methylation.
    J. Biol. Chem. 275 : 22196-22201 (2000). [PMID: 10896953]
  2. Nyyssölä, A., Reinikainen, T. and Leisola, M.
    Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase.
    Appl. Environ. Microbiol. 67 : 2044-2050 (2001). [PMID: 11319079]
  3. Waditee, R., Tanaka, Y., Aoki, K., Hibino, T., Jikuya, H., Takano, J., Takabe, T. and Takabe, T.
    Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.
    J. Biol. Chem. 278 : 4932-4942 (2003). [PMID: 12466265]

[EC created 2005, modified 2010]