IntEnz

EC 2.1.1.142 - Cycloartenol 24-C-methyltransferase

IntEnz Enzyme Nomenclature
EC 2.1.1.142

Names

Reaction

• 13137 [IUBMB]
  cycloartenol

  cycloartenol

  Name origin: UniProt - CHECKED (C)

  CHEBI:17030

  Formula: C30H50O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  S-adenosyl-L-methionine

  S-adenosyl-L-methionine

  Name origin: UniProt - CHECKED (C)

  CHEBI:59789

  Formula: C15H23N6O5S
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  =

  cyclolaudenol

  cyclolaudenol

  Name origin: UniProt - CHECKED (C)

  CHEBI:142990

  Formula: C31H52O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  S-adenosyl-L-homocysteine

  S-adenosyl-L-homocysteine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57856

  Formula: C14H20N6O5S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

Comments:

S-Adenosyl-L-methionine methylates the Si face of the 24(25)-double bond with elimination of a hydrogen atom from the pro-Z methyl group at C-25.

Links to other databases

References

1. Mangla, A.T. and Nes, W.D.
   Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition.
   Bioorg. Med. Chem. 8: 925-936 (2000). [PMID: 10882005]

[EC 2.1.1.142 created 2001, modified 2019]