EC 2.1.1.139 - 3'-demethylstaurosporine O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.139

Names

Accepted name:
3'-demethylstaurosporine O-methyltransferase
Other names:
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase
staurosporine synthase
Systematic name:
S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase

Reaction

Comments:

Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030793

References

  1. Weidner, S., Kittelmann, M., Goeke, K., Ghisalba, O. and Zahner, H.
    3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine.
    J. Antibiot. (Tokyo) 51: 679-682 (1998). [PMID: 9727395]

[EC 2.1.1.139 created 2000]