IntEnz

EC 2.1.1.133 - Precorrin-4 C¹¹-methyltransferase

IntEnz Enzyme Nomenclature
EC 2.1.1.133

Names

Reaction

• 22012 [IUBMB]
  precorrin-4

  precorrin-4

  Name origin: UniProt - CHECKED (C)

  CHEBI:57769

  Formula: C44H44N4O17
  Charge: -8

  ChEBI compound status: CHECKED (C)

  

  +

  S-adenosyl-L-methionine

  S-adenosyl-L-methionine

  Name origin: UniProt - CHECKED (C)

  CHEBI:59789

  Formula: C15H23N6O5S
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  =

  precorrin-5

  precorrin-5

  Name origin: UniProt - CHECKED (C)

  CHEBI:77871

  Formula: C45H47N4O17
  Charge: -7

  ChEBI compound status: CHECKED (C)

  

  +

  S-adenosyl-L-homocysteine

  S-adenosyl-L-homocysteine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57856

  Formula: C14H20N6O5S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

Comments:

In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.

Links to other databases

References

1. Crouzet, J., Cameron, B., Cauchois, L., Rigault, S., Rouyez, M.C., Blanche, F., Thibaut D. and Debussche, L.
   Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.
   J. Bacteriol. 172: 5980-5990 (1990). [PMID: 2211521]
2. Roth, J.R., Lawrence, J.G., Rubenfield, M., Kieffer-Higgins, S. and Church, G.M.
   Characterization of the cobalamin (vitamin B₁₂) biosynthetic genes of Salmonella typhimurium.
   J. Bacteriol. 175: 3303-3316 (1993). [PMID: 8501034]

[EC 2.1.1.133 created 1999]