EC - Precorrin-4 C11-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
precorrin-4 C11-methyltransferase
Other names:
precorrin-3 methylase
precorrin-4 C11-methyltransferase
Systematic name:
S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase



In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC, C-11 (CobM; EC and C-1 (CobF; EC of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively. See EC for the C11-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046026
CAS Registry Numbers: 132052-20-1 132053-02-2 9033-25-4


  1. Crouzet, J., Cameron, B., Cauchois, L., Rigault, S., Rouyez, M.C., Blanche, F., Thibaut D. and Debussche, L.
    Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.
    J. Bacteriol. 172 : 5980-5990 (1990). [PMID: 2211521]
  2. Roth, J.R., Lawrence, J.G., Rubenfield, M., Kieffer-Higgins, S. and Church, G.M.
    Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.
    J. Bacteriol. 175 : 3303-3316 (1993). [PMID: 8501034]

[EC created 1999]