EC 22.214.171.124 - Precorrin-4 C11-methyltransferase
IntEnz Enzyme Nomenclature
- S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5
In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 126.96.36.199 (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 188.8.131.52), C-11 (CobM; EC 184.108.40.206) and C-1 (CobF; EC 220.127.116.11) of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively. See EC 18.104.22.1681 for the C11-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
Links to other databases
Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.J. Bacteriol. 172 : 5980-5990 (1990). [PMID: 2211521]
Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.J. Bacteriol. 175 : 3303-3316 (1993). [PMID: 8501034]
[EC 22.214.171.124 created 1999]