EC - Precorrin-2 C20-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
precorrin-2 C20-methyltransferase
Other names:
S-adenosyl-L-methionine—precorrin-2 methyltransferase
precorrin-2 C20-methyltransferase
Systematic name:
S-adenosyl-L-methionine:precorrin-2 C20-methyltransferase



This enzyme participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway. See EC for the equivalent enzyme that participates in the anaerobic cobalamin biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030788
CAS Registry Number: 131554-12-6


  1. Roessner, C.A., Warren, M.J., Santander, P.J., Atshaves, B.P., Ozaki, S., Stolowich, N.J., Iida, K. and Scott, A.I.
    Expression of Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis.
    FEBS Lett. 301 : 73-78 (1992). [PMID: 1451790]
  2. Roessner, C.A., Spencer, J.B., Ozaki, S., Min, C., Atshaves, B.P., Nayar, P., Anousis, N., Stolowich, N.J., Holderman, M.T. and Scott, A.I.
    Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes.
    Protein Extr. Purif. 6 : 155-163 (1995). [PMID: 7606163]
  3. Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F.J.
    Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
    J. Bacteriol. 175 : 7430-7440 (1993). [PMID: 8226690]

[EC created 1999]