EC - Sterigmatocystin 8-O-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
sterigmatocystin 8-O-methyltransferase
Other names:
O-methyltransferase II
sterigmatocystin methyltransferase
sterigmatocystin 7-O-methyltransferase [incorrect]
S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase [incorrect]
Systematic name:
S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase



Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047146
CAS Registry Number: 116958-29-3


  1. Bhatnagar, D., McCormick, S.P., Lee, L.S. and Hill, R.A.
    Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus.
    Appl. Environ. Microbiol. 53 : 1028-1033 (1987). [PMID: 3111363]
  2. Yabe, K., Ando, Y., Hashimoto, J. and Hamasaki, T.
    Two distinct O-methyltransferases in aflatoxin biosynthesis.
    Appl. Environ. Microbiol. 55 : 2172-2177 (1989). [PMID: 2802602]
  3. Yu, J., Cary, J. W., Bhatnagar, D., Cleveland, T. E., Keller, N. P., Chu, F. S.
    Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis.
    Appl. Environ. Microbiol. 59 : 3564-3571 (1993). [PMID: 8285664]
  4. Lee, L. W., Chiou, C. H., Linz, J. E.
    Function of native OmtA in vivo and expression and distribution of this protein in colonies of Aspergillus parasiticus.
    Appl. Environ. Microbiol. 68 : 5718-5727 (2002). [PMID: 12406770]

[EC created 1992, modified 2005, modified 2013]