EC 1.8.98.4 - Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

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IntEnz Enzyme Nomenclature
EC 1.8.98.4

Names

Accepted name:
coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
Other name:
hdrA2B2C2 (gene names)
Systematic name:
CoB,CoM,ferredoxin:coenzyme F420 oxidoreductase

Reaction

Comments:

The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyses the reduction of CoB-CoM heterodisulfide back to CoB and CoM. The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters. Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB. During methanogenesis from acetate the enzyme catalyses the activity of EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase. However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Yan, Z., Wang, M. and Ferry, J.G.
    A ferredoxin- and F420H2-dependent, electron-bifurcating, heterodisulfide reductase with homologs in the domains Bacteria and Archaea.
    MBio. 8: e02285-16 (2017). [PMID: 28174314]

[EC 1.8.98.4 created 2017]