EC - Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

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IntEnz Enzyme Nomenclature


Accepted name:
coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
Other name:
hdrA2B2C2 (gene names)
Systematic name:
CoB,CoM,ferredoxin:coenzyme F420 oxidoreductase



The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyses the reduction of CoB-CoM heterodisulfide back to CoB and CoM. The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters. Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB. During methanogenesis from acetate the enzyme catalyses the activity of EC, ferredoxin:CoB-CoM heterodisulfide reductase. However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Yan, Z., Wang, M. and Ferry, J.G.
    A ferredoxin- and F420H2-dependent, electron-bifurcating, heterodisulfide reductase with homologs in the domains Bacteria and Archaea.
    MBio. 8: e02285-16 (2017). [PMID: 28174314]

[EC created 2017]