EC - Dihydromethanophenazine:CoB—CoM heterodisulfide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
dihydromethanophenazine:CoB—CoM heterodisulfide reductase
Other names:
heterodisulfide reductase [ambiguous]
hdrDE (gene names)
CoB—CoM heterodisulfide reductase [ambiguous]
coenzyme B:coenzyme M:methanophenazine oxidoreductase
Systematic name:
CoB:CoM:methanophenazine oxidoreductase




This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC, ferredoxin:CoB-CoM heterodisulfide reductase, EC, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051912


  1. Hedderich, R., Berkessel, A. and Thauer, R.K.
    Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
    Eur. J. Biochem. 193: 255-261 (1990). [PMID: 2121478]
  2. Abken, H.J., Tietze, M., Brodersen, J., Bäumer, S., Beifuss, U. and Deppenmeier, U.
    Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei gol.
    J. Bacteriol. 180: 2027-2032 (1998). [PMID: 9555882]
  3. Simianu, M., Murakami, E., Brewer, J.M. and Ragsdale, S.W.
    Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila.
    Biochemistry 37: 10027-10039 (1998). [PMID: 9665708]
  4. Murakami, E., Deppenmeier, U. and Ragsdale, S.W.
    Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophilo.
    J. Biol. Chem. 276: 2432-2439 (2001). [PMID: 11034998]

[EC created 2003, modified 2017]