EC - Thiosulfate reductase (quinone)

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IntEnz Enzyme Nomenclature


Accepted name:
thiosulfate reductase (quinone)
Other name:
phsABC (gene names)
Systematic name:
sulfite,hydrogen sulfide:quinone oxidoreductase




The enzyme, characterized from the bacterium Salmonella enterica, is similar to EC, formate dehydrogenase-N. It contains a molybdopterin-guanine dinucleotide, five [4Fe-4S] clusters and two heme b groups. The reaction occurs in vivo in the direction of thiosulfate disproportionation, which is highly endergonic. It is driven by the proton motive force that occurs across the cytoplasmic membrane.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kwan, H. S., Barrett, E. L.
    Map locations and functions of Salmonella typhimurium men genes.
    J. Bacteriol. 159: 1090-1092 (1984). [PMID: 6384182]
  2. Clark, M. A., Barrett, E. L.
    The phs gene and hydrogen sulfide production by Salmonella typhimurium.
    J. Bacteriol. 169: 2391-2397 (1987). [PMID: 3108233]
  3. Alami, N., Hallenbeck, P. C.
    Cloning and characterization of a gene cluster, phsBCDEF, necessary for the production of hydrogen sulfide from thiosulfate by Salmonella typhimurium.
    Gene 156: 53-57 (1995). [PMID: 7737516]
  4. Heinzinger, N. K., Fujimoto, S. Y., Clark, M. A., Moreno, M. S., Barrett, E. L.
    Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.
    J. Bacteriol. 177: 2813-2820 (1995). [PMID: 7751291]
  5. Stoffels, L., Krehenbrink, M., Berks, B. C., Unden, G.
    Thiosulfate reduction in Salmonella enterica is driven by the proton motive force.
    J. Bacteriol. 194: 475-485 (2012). [PMID: 22081391]

[EC created 2016, modified 2017]