EC - Dimethylsulfoxide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
dimethylsulfoxide reductase
Other name:
DMSO reductase
Systematic name:
dimethylsulfide:menaquinone oxidoreductase




Contains molybdopterin and [4Fe-4S] clusters. Also reduces pyridine N-oxide and trimethylamine N-oxide, with lower activity, to the corresponding amines.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Simala-Grant, J. L., Weiner, J. H.
    Kinetic analysis and substrate specificity of Escherichia coli dimethyl sulfoxide reductase.
    Microbiology 142: 3231-3239 (1996). [PMID: 8969520]
  2. Daruwala, R., Meganathan, R.
    Dimethyl sulfoxide reductase is not required for trimethylamine N-oxide reduction in Escherichia coli.
    FEMS Microbiol. Lett. 67: 255-259 (1991). [PMID: 1769531]
  3. Miguel, L. and Meganthan, R.
    Electron-donors and the quinone involved in dimethyl-sulfoxide reduction in Escherichia coli.
    Curr. Microbiol. 22: 109-115 (1991).
  4. Rothery, R. A., Trieber, C. A., Weiner, J. H.
    Interactions between the molybdenum cofactor and iron-sulfur clusters of Escherichia coli dimethylsulfoxide reductase.
    J. Biol. Chem. 274: 13002-13009 (1999). [PMID: 10224050]

[EC created 2011]