EC - Enzyme-thiol transhydrogenase (glutathione-disulfide)

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IntEnz Enzyme Nomenclature


Accepted name:
enzyme-thiol transhydrogenase (glutathione-disulfide)
Other names:
[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase
enzyme-thiol transhydrogenase (oxidized-glutathione)
glutathione-dependent thiol:disulfide oxidoreductase
thiol:disulphide oxidoreductase
Systematic name:
[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase



Converts EC xanthine dehydrogenase into EC xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047142
CAS Registry Number: 85030-79-1


  1. Battelli, M.G. and Lorenzoni, E.
    Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver.
    Biochem. J. 207 : 133-138 (1982). [PMID: 6960894]

[EC created 1989, modified 2002]