EC - Protein-disulfide reductase (glutathione)

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IntEnz Enzyme Nomenclature


Accepted name:
protein-disulfide reductase (glutathione)
Other names:
GSH—insulin transhydrogenase
glutathione—insulin transhydrogenase
glutathione—protein disulfide oxidoreductase
insulin reductase
protein disulfide reductase (glutathione)
protein disulfide transhydrogenase
protein-disulfide interchange enzyme
protein-disulfide isomerase/oxidoreductase
reductase, protein disulfide (glutathione)
thiol:protein-disulfide oxidoreductase
thiol—protein disulphide oxidoreductase
Systematic name:
glutathione:protein-disulfide oxidoreductase



Reduces insulin and some other proteins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00172
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019153
CAS Registry Number: 9082-53-5


  1. Katzen, H.M., Tietze, F. and Stetten, D., Jr.
    Further studies on the properties of hepatic glutathione-insulin transhydrogenase.
    J. Biol. Chem. 238 : 1006-1011 (1963). [PMID: 14031343]
  2. Kohnert, K.-D., Hahn, H.-J., Zühlke, H., Schmidt, S. and Fiedler, H.
    Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.
    Biochim. Biophys. Acta 338 : 68-77 (1974).

[EC created 1965]