EC 1.8.4.14 - L-methionine (R)-S-oxide reductase

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IntEnz Enzyme Nomenclature
EC 1.8.4.14

Names

Accepted name:
L-methionine (R)-S-oxide reductase
Other names:
fRMsr
FRMsr
free met-R-(o) reductase
free-methionine (R)-S-oxide reductase
Systematic name:
L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]

Reaction

Cofactor

Comments:

Requires NADPH. Unlike EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC 1.8.4.13, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033745
CAS Registry Number: 945954-12-1
UniProtKB/Swiss-Prot: (16) [show] [UniProt]

References

  1. Etienne, F., Spector, D., Brot, N. and Weissbach, H.
    A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide.
    Biochem. Biophys. Res. Commun. 300: 378-382 (2003). [PMID: 12504094]

[EC 1.8.4.14 created 1984 as EC 1.8.4.5, part-transferred 2006 to EC 1.8.4.14]