EC - L-methionine (S)-S-oxide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
L-methionine (S)-S-oxide reductase
Other names:
L-methionine:oxidized-thioredoxin S-oxidoreductase
acetylmethionine sulfoxide reductase
methionine sulfoxide reductase
methyl sulfoxide reductase I and II
methionine-S-oxide reductase
free-methionine (S)-S-oxide reductase
Systematic name:
L-methionine:thioredoxin-disulfide S-oxidoreductase




Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC, L-methionine (R)-S-oxide reductase].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033744


  1. Black, S., Harte, E.M., Hudson, B. and Wartofsky, L.
    A specific enzymatic reduction of L(−) methionine sulfoxide and a related nonspecific reduction of disulfides.
    J. Biol. Chem. 235 : 2910-2916 (1960).
  2. Ejiri, S.-I., Weissbach, H. and Brot, N.
    Reduction of methionine sulfoxide to methionine by Escherichia coli.
    J. Bacteriol. 139 : 161-164 (1979). [PMID: 37234]
  3. Ejiri, S.-I., Weissbach, H. and Brot, N.
    The purification of methionine sulfoxide reductase from Escherichia coli.
    Anal. Biochem. 102 : 393-398 (1980). [PMID: 6999943]
  4. Weissbach, H., Resnick, L. and Brot, N.
    Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.
    Biochim. Biophys. Acta 1703 : 203-212 (2005). [PMID: 15680228]

[EC, created 1984 as EC, part-transferred 2006 to EC]