EC 22.214.171.124 - L-methionine (S)-S-oxide reductase
IntEnz Enzyme Nomenclature
acetylmethionine sulfoxide reductase
methionine sulfoxide reductase
methyl sulfoxide reductase I and II
free-methionine (S)-S-oxide reductase
- L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin
Requires NADPH . The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 126.96.36.199, L-methionine (R)-S-oxide reductase].
Links to other databases
A specific enzymatic reduction of L(−) methionine sulfoxide and a related nonspecific reduction of disulfides.J. Biol. Chem. 235 : 2910-2916 (1960).
Reduction of methionine sulfoxide to methionine by Escherichia coli.J. Bacteriol. 139 : 161-164 (1979). [PMID: 37234]
The purification of methionine sulfoxide reductase from Escherichia coli.Anal. Biochem. 102 : 393-398 (1980). [PMID: 6999943]
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.Biochim. Biophys. Acta 1703 : 203-212 (2005). [PMID: 15680228]
[EC 188.8.131.52, created 1984 as EC 184.108.40.206, part-transferred 2006 to EC 220.127.116.11]