EC - Prenylcysteine oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
prenylcysteine oxidase
Other name:
prenylcysteine lyase
Systematic name:
S-prenyl-L-cysteine:oxygen oxidoreductase




A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase, EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0001735


  1. Zhang, L., Tschantz, W.R. and Casey, P.J.
    Isolation and characterization of a prenylcysteine lyase from bovine brain.
    J. Biol. Chem. 272: 23354-23359 (1997). [PMID: 9287348]
  2. Tschantz, W.R., Digits, J.A., Pyun, H.J., Coates, R.M. and Casey, P.J.
    Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.
    J. Biol. Chem. 276: 2321-2324 (2001). [PMID: 11078725]

[EC created 2000 as EC, transferred 2002 to EC]