EC - Thiol oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
thiol oxidase
Other name:
sulfhydryl oxidase
Systematic name:
thiol:oxygen oxidoreductase



R may be =S or =O, or a variety of other groups. The enzyme is not specific for R'.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016972
CAS Registry Number: 9029-39-4
UniProtKB/Swiss-Prot: (47) [show] [UniProt]


  1. Aurbach, G.D. and Jakoby, W.B.
    The multiple functions of thiooxidase.
    J. Biol. Chem. 237 : 565-568 (1962). [PMID: 13863296]
  2. Neufeld, H.A., Green, L.F., Latterell, F.M. and Weintraub, R.L.
    Thiooxidase, a new sulfhydryl-oxidizing enzyme from Piricularia oryzae and Polyporus versicolor.
    J. Biol. Chem. 232 : 1093-1099 (1958). [PMID: 13549489]
  3. Ostrowski, M. C., Kistler, W. S.
    Properties of a flavoprotein sulfhydryl oxidase from rat seminal vesicle secretion.
    Biochemistry 19 : 2639-2645 (1980). [PMID: 7397095]
  4. Hoober, K. L., Joneja, B., White, H. B., Thorpe, C.
    A sulfhydryl oxidase from chicken egg white.
    J. Biol. Chem. 271 : 30510-30516 (1996). [PMID: 8940019]
  5. Jaje, J., Wolcott, H. N., Fadugba, O., Cripps, D., Yang, A. J., Mather, I. H., Thorpe, C.
    A flavin-dependent sulfhydryl oxidase in bovine milk.
    Biochemistry 46 : 13031-13040 (2007). [PMID: 17944490]
  6. Sevier, C. S., Cuozzo, J. W., Vala, A., Aslund, F., Kaiser, C. A.
    A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation.
    Nat. Cell Biol. 3 : 874-882 (2001). [PMID: 11584268]
  7. Dabir, D. V., Leverich, E. P., Kim, S. K., Tsai, F. D., Hirasawa, M., Knaff, D. B., Koehler, C. M.
    A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1.
    EMBO J. 26 : 4801-4811 (2007). [PMID: 17972915]
  8. Farrell, S. R., Thorpe, C.
    Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity.
    Biochemistry 44 : 1532-1541 (2005). [PMID: 15683237]
  9. Gross, E., Sevier, C. S., Heldman, N., Vitu, E., Bentzur, M., Kaiser, C. A., Thorpe, C., Fass, D.
    Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p.
    Proc. Natl. Acad. Sci. USA 103 : 299-304 (2006). [PMID: 16407158]
  10. de la Motte, R. S., Wagner, F. W.
    Aspergillus niger sulfhydryl oxidase.
    Biochemistry 26 : 7363-7371 (1987). [PMID: 3427078]
  11. Riemer, J., Bulleid, N., Herrmann, J. M.
    Disulfide formation in the ER and mitochondria: two solutions to a common process.
    Science 324 : 1284-1287 (2009). [PMID: 19498160]

[EC created 1961, modified 2011]