EC - Thiosulfate reductase (cytochrome)

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IntEnz Enzyme Nomenclature


Accepted name:
thiosulfate reductase (cytochrome)
Systematic name:
sulfite,hydrogen sulfide:ferricytochrome-c3 oxidoreductase (thiosulfate-forming)



The enzyme is found in sulfate-reducing bacteria. The source of the electrons is molecular hydrogen, via EC, cytochrome-c3 hydrogenase. The organisms utilize the sulfite that is produced for energy generation by EC, dissimilatory sulfite reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Ishimoto, M. and Koyama, J.
    On the role of a cytochrome in the thiosulfate reduction by sulfate-reducing bacterium.
    B. Chem. Soc. Jpn. 28 : 231-232 (1955).
  2. Ishimoto, M., Toyama, J.
    Biochemical studies on sulfate reducing bacteria. VI. Separation of hydrogenase and thiosulfate reductase and partial purification of cytochrome and green pigment.
    J. Biochem. (Tokyo) 44 : 233-242 (1955).
  3. Nakatsukasa, W., Akagi, J. M.
    Thiosulfate reductase isolated from Desulfotomaculum nigrificans.
    J. Bacteriol. 98 : 429-433 (1969). [PMID: 5784203]
  4. Haschke, R. H., Campbell, L. L.
    Thiosulfate reductase of Desulfovibrio vulgaris.
    J. Bacteriol. 106 : 603-607 (1971). [PMID: 5573735]
  5. Hatchikian, E. C.
    Purification and properties of thiosulfate reductase from Desulfovibrio gigas.
    Arch. Microbiol. 105 : 249-256 (1975). [PMID: 242299]
  6. Aketagawa, J., Kobayashi, K., Ishimoto, M.
    Purification and properties of thiosulfate reductase from Desulfovibrio vulgaris, Miyazaki F.
    J. Biochem. 97 : 1025-1032 (1985). [PMID: 2993256]

[EC created 2017]