EC - Thioredoxin-disulfide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
thioredoxin-disulfide reductase
Other names:
NADP—thioredoxin reductase
NADPH—thioredoxin reductase
NADPH2:oxidized thioredoxin oxidoreductase
thioredoxin reductase (NADPH)
Systematic name:
thioredoxin:NADP+ oxidoreductase



A flavoprotein (FAD).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00496
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004791
CAS Registry Number: 9074-14-0
UniProtKB/Swiss-Prot: (114) [show] [UniProt]


  1. Moore, E.C., Reichard, P. and Thelander, L.
    Enzymatic synthesis of deoxyribonucleotides. V. Purification and properties of thioredoxin reductase from Escherichia coli B.
    J. Biol. Chem. 239 : 3445-3452 (1964).
  2. Speranza, M.L., Ronchi, S. and Minchiotti, L.
    Purification and characterization of yeast thioredoxin reductase.
    Biochim. Biophys. Acta 327 : 274-281 (1973). [PMID: 4149839]
  3. Arner, E.S. and Holmgren, A.
    Physiological functions of thioredoxin and thioredoxin reductase.
    Eur. J. Biochem. 267 : 6102-6109 (2000). [PMID: 11012661]

[EC created 1972 as EC, transferred 2002 to EC]