EC - Glutathione-disulfide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
glutathione-disulfide reductase
Other names:
GSH reductase
GSSG reductase
NADPH-GSSG reductase
NADPH-glutathione reductase
NADPH:oxidized-glutathione oxidoreductase
glutathione S-reductase
glutathione reductase
glutathione reductase (NADPH)
Systematic name:
glutathione:NADP+ oxidoreductase




A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00073
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004362
CAS Registry Number: 9001-48-3
UniProtKB/Swiss-Prot: (41) [show] [UniProt]


  1. Pai, E.F., Schirmer, R.H. and Schulz, G.E.
    Structural studies on crystalline glutathione reductase from human erythrocytes.
    In: Singer, T.P. and Ondarza, R.N. (Eds.) Mechanisms of Oxidizing Enzymes , Elsevier North Holland , New York , 1978 , 17-22
  2. Pigiet, V.P. and Conley, R.R.
    Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography.
    J. Biol. Chem. 252 : 6367-6372 (1977). [PMID: 330529]
  3. Racker, E.
    Glutathione reductase from bakers' yeast and beef liver.
    J. Biol. Chem. 217 : 855-865 (1955).
  4. van Heyningen, R. and Pirie, A.
    Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens.
    Biochem. J. 53 : 436-444 (1953).
  5. Worthington, D.J. and Rosemeyer, M.A.
    Glutathione reductase from human erythrocytes. Catalytic properties and aggregation.
    Eur. J. Biochem. 67 : 231-238 (1976). [PMID: 9277]
  6. Böhmé, C.C., Arscott, L.D., Becker, K., Schirmer, R.H. and Williams, C.H., Jr.
    Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme.
    J. Biol. Chem. 275 : 37317-37323 (2000). [PMID: 10969088]
  7. Libreros-Minotta, C.A., Pardo, J.P., Mendoza-Hernandez, G. and Rendon, J.L.
    Purification and characterization of glutathione reductase from Rhodospirillum rubrum.
    Arch Biochem Biophys 298 : 247-253 (1992). [PMID: 1524433]

[EC created 1961 as EC, modified 1989, transferred 2002 to EC]