EC 1 - Oxidoreductases
EC 1.8 - Acting on a sulfur group of donors
EC 1.8.1 - With NAD+ or NADP+ as acceptor
EC 1.8.1.7 - Glutathione-disulfide reductase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.8.1.7
Names
Accepted name:
glutathione-disulfide reductase
Other
names:
GSH reductase
GSSG reductase
NADPH-GSSG reductase
NADPH-glutathione reductase
NADPH:oxidized-glutathione oxidoreductase
glutathione S-reductase
glutathione reductase
glutathione reductase (NADPH)
GSSG reductase
NADPH-GSSG reductase
NADPH-glutathione reductase
NADPH:oxidized-glutathione oxidoreductase
glutathione S-reductase
glutathione reductase
glutathione reductase (NADPH)
Systematic name:
glutathione:NADP+ oxidoreductase
Reaction
- 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
Cofactor
Comments:
A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00073
Gene Ontology:
GO:0004362
CAS Registry Number:
9001-48-3
References
-
Structural studies on crystalline glutathione reductase from human erythrocytes.In: Singer, T.P. and Ondarza, R.N. (Eds.) Mechanisms of Oxidizing Enzymes , Elsevier North Holland , New York , 1978 , 17-22
-
Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography.J. Biol. Chem. 252 : 6367-6372 (1977). [PMID: 330529]
-
Glutathione reductase from bakers' yeast and beef liver.J. Biol. Chem. 217 : 855-865 (1955).
-
Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens.Biochem. J. 53 : 436-444 (1953).
-
Glutathione reductase from human erythrocytes. Catalytic properties and aggregation.Eur. J. Biochem. 67 : 231-238 (1976). [PMID: 9277]
-
Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme.J. Biol. Chem. 275 : 37317-37323 (2000). [PMID: 10969088]
-
Purification and characterization of glutathione reductase from Rhodospirillum rubrum.Arch Biochem Biophys 298 : 247-253 (1992). [PMID: 1524433]
[EC 1.8.1.7 created 1961 as EC 1.6.4.2, modified 1989, transferred 2002 to EC 1.8.1.7]