EC - 2-oxopropyl-CoM reductase (carboxylating)

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxopropyl-CoM reductase (carboxylating)
Other names:
NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase
Systematic name:
2-sulfanylethane-1-sulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)



Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-sulfanylethane-1-sulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system {comprising EC (2-hydroxypropyl-CoM lyase; component I), EC [2-oxopropyl-CoM reductase (carboxylating); component II], EC [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050628


  1. Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A.
    A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation.
    Proc. Natl. Acad. Sci. USA 96 : 8432-8437 (1999). [PMID: 10411892]
  2. Clark, D.D., Allen, J.R. and Ensign, S.A.
    Characterization of five catalytic activities associated with the NADPH:2-ketopropyl-coenzyme M [2-(2-ketopropylthio)ethanesulfonate] oxidoreductase/carboxylase of the Xanthobacter strain Py2 epoxide carboxylase system.
    Biochemistry 39 : 1294-1304 (2000). [PMID: 10684609]

[EC created 2001]