EC - CoA-disulfide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
CoA-disulfide reductase
Other names:
CoA-disulfide reductase (NADH2)
NADH2:CoA-disulfide oxidoreductase
coenzyme A disulfide reductase
NADH:CoA-disulfide oxidoreductase
CoA-disulfide reductase [NAD(P)H]
CoA:NAD+ oxidoreductase [misleading]
Systematic name:
CoA:NADP+ oxidoreductase




A flavoprotein. Not identical with EC (cystine reductase), EC (glutathione-disulfide reductase) or EC (bis-γ-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050451
CAS Registry Number: 206770-55-0
UniProtKB/Swiss-Prot: (22) [show] [UniProt]


  1. Setlow, B. and Setlow, P.
    Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium.
    J. Bacteriol. 132 : 444-452 (1977). [PMID: 410791]
  2. delCardayré, S.B., Stock, K.P., Newton, G.L., Fahey, R.C. and Davies, J.E.
    Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.
    J. Biol. Chem. 273 : 5744-5751 (1998). [PMID: 9488707]
  3. Luba, J., Charrier, V. and Claiborne, A.
    Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.
    Biochemistry 38 : 2725-2737 (1999). [PMID: 10052943]

[EC created 1992 as EC, transferred 2002 to EC, modified 2005, modified 2013]