EC 1.8.1.13 - Bis-γ-glutamylcystine reductase

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IntEnz Enzyme Nomenclature
EC 1.8.1.13

Names

Accepted name:
bis-γ-glutamylcystine reductase
Other names:
NADPH2:bis-γ-glutamylcysteine oxidoreductase
bis-γ-glutamylcystine reductase (NADPH)
NADPH:bis-γ-glutamylcysteine oxidoreductase
Systematic name:
γ-glutamylcysteine:NADP+ oxidoreductase

Reaction

Cofactor

Comments:

Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of γ-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.14 (CoA-disulfide reductase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047135
CAS Registry Number: 117056-54-9

References

  1. Sundquist, A.R. and Fahey, R.C.
    The novel disulfide reductase bis-γ-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes.
    J. Bacteriol. 170: 3459-3467 (1988). [PMID: 3136140]
  2. Sundquist, A.R. and Fahey, R.C.
    The function of γ-glutamylcysteine and bis-γ-glutamylcystine reductase in Halobacterium halobium.
    J. Biol. Chem. 264: 719-725 (1989). [PMID: 2910862]
  3. Kim, J., Copley, S. D.
    The orphan protein bis-γ-glutamylcystine reductase joins the pyridine nucleotide disulfide reductase family.
    Biochemistry 52: 2905-2913 (2013). [PMID: 23560638]

[EC 1.8.1.13 created 1992 as EC 1.6.4.9, transferred 2002 to EC 1.8.1.13]