EC - CoA-glutathione reductase

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IntEnz Enzyme Nomenclature


Accepted name:
CoA-glutathione reductase
Other names:
NADPH-dependent coenzyme A-SS-glutathione reductase
NADPH2:CoA-glutathione oxidoreductase
coenzyme A disulfide-glutathione reductase
coenzyme A glutathione disulfide reductase
Systematic name:
glutathione:NADP+ oxidoreductase (CoA-acylating)




A flavoprotein. The substrate is a mixed disulfide. May be identical to EC, thioredoxin-disulfide reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050452
CAS Registry Number: 37256-33-0


  1. Ondarza, R.N., Abney, R. and López-Colomé, A.M.
    Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast.
    Biochim. Biophys. Acta 191: 239-248 (1969). [PMID: 4390951]
  2. Ondarza, R.N., Escamilla, E., Gutierrez, J. and De la Chica, G.
    CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity.
    Biochim. Biophys. Acta 341: 162-171 (1974). [PMID: 4151341]
  3. Carlberg, I. and Mannervik, B.
    Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione.
    Biochim. Biophys. Acta 484: 268-274 (1977). [PMID: 334266]

[EC created 1972 as EC, transferred 2002 to EC]