EC - Hydrazine dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
hydrazine dehydrogenase
Other name:
HDH [ambiguous]
Systematic name:
hydrazine:ferricytochrome c oxidoreductase



The enzyme, which is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria, has been purified from the bacterium Candidatus Kuenenia stuttgartiensis. The electrons derived from hydrazine are eventually transferred to the quinone pool. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033740


  1. Schalk, J., de Vries, S., Kuenen, J.G. and Jetten, M.S.M.
    Involvement of a novel hydroxylamine oxidoreductase in anaerobic ammonium oxidation.
    Biochemistry 39 : 5405-5412 (2000). [PMID: 10820012]
  2. Jetten, M.S.M., Wagner, M., Fuerst, J., van Loosdrecht, M., Kuenen, G. and Strous, M.
    Microbiology and application of the anaerobic ammonium oxidation ('anammox') process.
    Curr. Opin. Biotechnol. 12 : 283-288 (2001). [PMID: 11404106]
  3. Kartal, B., Maalcke, W. J., de Almeida, N. M., Cirpus, I., Gloerich, J., Geerts, W., Op den Camp, H. J., Harhangi, H. R., Janssen-Megens, E. M., Francoijs, K. J., Stunnenberg, H. G., Keltjens, J. T., Jetten, M. S., Strous, M.
    Molecular mechanism of anaerobic ammonium oxidation.
    Nature 479 : 127-130 (2011). [PMID: 21964329]
  4. Kartal, B., de Almeida, N. M., Maalcke, W. J., Op den Camp, H. J., Jetten, M. S., Keltjens, J. T.
    How to make a living from anaerobic ammonium oxidation.
    FEMS Microbiol. Rev. 37 : 428-461 (2013). [PMID: 23210799]

[EC created 2003 as EC, modified 2010, transferred 2016 to EC]