EC - Nitrous-oxide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
nitrous-oxide reductase
Other names:
N2O reductase
nitrous oxide reductase
nitrogen:(acceptor) oxidoreductase (N2O-forming)
Systematic name:
nitrogen:cytochrome c oxidoreductase (N2O-forming)




The reaction is observed only in the direction of nitrous oxide reduction. Contains the mixed-valent dinuclear CuA species at the electron entry site of the enzyme, and the tetranuclear Cu-Z centre in the active site. In Paracoccus pantotrophus, the electron donor is cytochrome c552.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050304
CAS Registry Number: 55576-44-8
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Coyle, C.L., Zumft, W.G., Kroneck, P.M.H., Körner, H. and Jakob, W.
    Nitrous oxide reductase from denitrifying Pseudomonas perfectomarina. Purification and properties of a novel multicopper enzyme.
    Eur. J. Biochem. 153: 459-467 (1985). [PMID: 3000778]
  2. Zumft, W. G., Kroneck, P. M.
    Respiratory transformation of nitrous oxide (N2O) to dinitrogen by Bacteria and Archaea.
    Adv. Microb. Physiol. 52: 107-227 (2007). [PMID: 17027372]
  3. Dell'Acqua, S., Pauleta, S. R., Paes de Sousa, P. M., Monzani, E., Casella, L., Moura, J. J., Moura, I.
    A new CuZ active form in the catalytic reduction of N2O by nitrous oxide reductase from Pseudomonas nautica.
    J. Biol. Inorg. Chem. 15: 967-976 (2010). [PMID: 20422435]

[EC created 1989 as EC, modified 1999, transferred 2011 to EC]