EC - Azobenzene reductase

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IntEnz Enzyme Nomenclature


Accepted name:
azobenzene reductase
Other names:
N,N-dimethyl-4-phenylazoaniline azoreductase
p-aminoazobenzene reductase
p-dimethylaminoazobenzene azoreductase
NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase
NADPH2-dependent azoreductase
NADPH2:4-(dimethylamino)azobenzene oxidoreductase
azo reductase
azo-dye reductase
dibromopropylaminophenylazobenzoic azoreductase
dimethylaminobenzene reductase
methyl red azoreductase
new coccine (NC)-reductase
nicotinamide adenine dinucleotide (phosphate) azoreductase
orange I azoreductase
orange II azoreductase
NADPH-dependent azoreductase
NADPH:4-(dimethylamino)azobenzene oxidoreductase
Systematic name:
N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase



The reaction occurs in the reverse direction to that shown above. Other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B can also be reduced [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050446
CAS Registry Number: 9029-31-6


  1. Mueller, G.C. and Miller, J.A.
    The reductive cleavage of 4-dimethylaminoazobenzene by rat liver: the intracellular distribution of the enzyme system and its requirements for triphosphopyridine nucleotide.
    J. Biol. Chem. 180 : 1125-1136 (1949).
  2. Suzuki, Y., Yoda, T., Ruhul, A. and Sugiura, W.
    Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil.
    J. Biol. Chem. 276 : 9059-9065 (2001). [PMID: 11134015]

[EC created 1961 as EC, transferred 2002 to EC]