EC - Nitrite reductase [NAD(P)H]

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
nitrite reductase [NAD(P)H]
Other names:
NAD(P)H2:nitrite oxidoreductase
NADH-nitrite oxidoreductase
NADPH-nitrite reductase
assimilatory nitrite reductase [ambiguous]
nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate))
nitrite reductase [NAD(P)H2]
NAD(P)H:nitrite oxidoreductase
nit-6 (gene name)
Systematic name:
ammonia:NAD(P)+ oxidoreductase




An iron-sulfur flavoprotein (FAD) containing siroheme. The enzymes from the fungi Neurospora crassa [1], Emericella nidulans [2] and Candida nitratophila [4] can use either NADPH or NADH as electron donor. cf. EC, nitrite reductase (NADH).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008942
CAS Registry Number: 9029-29-2


  1. Nicholas, D.J.D., Medina, A. and Jones, O.T.G.
    A nitrite reductase from Neurospora crassa.
    Biochim. Biophys. Acta 37 : 468-476 (1960).
  2. Pateman, J. A., Rever, B. M., Cove, D. J.
    Genetic and biochemical studies of nitrate reduction in Aspergillus nidulans.
    Biochem. J. 104 : 103-111 (1967). [PMID: 4382427]
  3. Rivas, J., Guerrero, M. G., Paneque, A. and Losada, M.
    Characterization of the nitrate-reducing system of the yeast Torulopsis nitratophila.
    Plant Sci. Lett. 1 : 105-113 (1973).
  4. Lafferty, M. A., Garrett, R. H.
    Purification and properties of the Neurospora crassa assimilatory nitrite reductase.
    J. Biol. Chem. 249 : 7555-7567 (1974). [PMID: 4154942]
  5. Vega, J. M., Garrett, R. H.
    Siroheme: a prosthetic group of the Neurospora crassa assimilatory nitrite reductase.
    J. Biol. Chem. 250 : 7980-7989 (1975). [PMID: 126995]
  6. Greenbaum, P., Prodouz, K. N., Garrett, R. H.
    Preparation and some properties of homogeneous Neurospora crassa assimilatory NADPH-nitrite reductase.
    Biochim. Biophys. Acta 526 : 52-64 (1978). [PMID: 150863]
  7. Prodouz, K. N., Garrett, R. H.
    Neurospora crassa NAD(P)H-nitrite reductase. Studies on its composition and structure.
    J. Biol. Chem. 256 : 9711-9717 (1981). [PMID: 6457037]
  8. Exley, G. E., Colandene, J. D., Garrett, R. H.
    Molecular cloning, characterization, and nucleotide sequence of nit-6, the structural gene for nitrite reductase in Neurospora crassa.
    J. Bacteriol. 175 : 2379-2392 (1993). [PMID: 8096840]
  9. Colandene, J. D., Garrett, R. H.
    Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa.
    J. Biol. Chem. 271 : 24096-24104 (1996). [PMID: 8798648]

[EC created 1961 as EC, transferred 2002 to EC, modified 2013]