EC 1.7.1.15 - Nitrite reductase (NADH)

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IntEnz Enzyme Nomenclature
EC 1.7.1.15

Names

Accepted name:
nitrite reductase (NADH)
Other names:
nitrite reductase (reduced nicotinamide adenine dinucleotide)
NADH-nitrite oxidoreductase
assimilatory nitrite reductase [ambiguous]
nirB (gene name)
nirD (gene name)
Systematic name:
ammonia:NAD+ oxidoreductase

Reaction

Cofactors

Comments:

An iron-sulfur flavoprotein (FAD) containing siroheme. This prokaryotic enzyme is specific for NADH. In addition to catalysing the 6-electron reduction of nitrite to ammonia, the enzyme from Escherichia coli can also catalyse the 2-electron reduction of hydroxylamine to ammonia. cf. EC 1.7.1.4, nitrite reductase [NAD(P)H].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Vega, J. M., Guerrero, M. G., Leadbetter, E., Losada, M.
    Reduced nicotinamide-adenine dinucleotide-nitrite reductase from Azotobacter chroococcum.
    Biochem. J. 133: 701-708 (1973). [PMID: 4147887]
  2. Jackson, R. H., Cornish-Bowden, A., Cole, J. A.
    Prosthetic groups of the NADH-dependent nitrite reductase from Escherichia coli K12.
    Biochem. J. 193: 861-867 (1981). [PMID: 7030314]
  3. Cammack, R., Jackson, R. H., Cornish-Bowden, A., Cole, J. A.
    Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12.
    Biochem. J. 207: 333-339 (1982). [PMID: 6297458]
  4. Harborne, N. R., Griffiths, L., Busby, S. J., Cole, J. A.
    Transcriptional control, translation and function of the products of the five open reading frames of the Escherichia coli nir operon.
    Mol. Microbiol. 6: 2805-2813 (1992). [PMID: 1435259]

[EC 1.7.1.15 created 2013]