IntEnz

EC 1.6.5.10 - NADPH dehydrogenase (quinone)

IntEnz Enzyme Nomenclature
EC 1.6.5.10

Names

Reaction

• 46164 [IUBMB]
  a quinone

  a quinone

  Name origin: UniProt - CHECKED (C)

  CHEBI:132124

  Formula: C6O2R4
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADPH

  NADPH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57783

  Formula: C21H26N7O17P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  a quinol

  a quinol

  Name origin: UniProt - CHECKED (C)

  CHEBI:24646

  Formula: C6H2O2R4
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADP⁺

  NADP(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58349

  Formula: C21H25N7O17P3
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

Cofactor

• flavoprotein

Comments:

A flavoprotein [1,2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3]. Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].

Links to other databases

References

1. Koli, A.K., Yearby, C., Scott, W. and Donaldson, K.O.
   Purification and properties of three separate menadione reductases from hog liver.
   J. Biol. Chem. 244 : 621-629 (1969). [PMID: 4388793]
2. Hayashi, M., Hasegawa, K., Oguni, Y., Unemoto, T.
   Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli.
   Biochim. Biophys. Acta 1035 : 230-236 (1990). [PMID: 2118386]
3. Hayashi, M., Ohzeki, H., Shimada, H., Unemoto, T.
   NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli.
   Biochim. Biophys. Acta 1273 : 165-170 (1996). [PMID: 8611590]

[EC 1.6.5.10 created 1972 as EC 1.6.99.6, transferred 2011 to EC 1.6.5.10]