EC - NADPH dehydrogenase (quinone)

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IntEnz Enzyme Nomenclature


Accepted name:
NADPH dehydrogenase (quinone)
Other names:
NADPH oxidase
reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase
NADPH2 dehydrogenase (quinone)
Systematic name:
NADPH:(quinone-acceptor) oxidoreductase




A flavoprotein [1,2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3]. Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008753
CAS Registry Number: 37256-37-4


  1. Koli, A.K., Yearby, C., Scott, W. and Donaldson, K.O.
    Purification and properties of three separate menadione reductases from hog liver.
    J. Biol. Chem. 244 : 621-629 (1969). [PMID: 4388793]
  2. Hayashi, M., Hasegawa, K., Oguni, Y., Unemoto, T.
    Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli.
    Biochim. Biophys. Acta 1035 : 230-236 (1990). [PMID: 2118386]
  3. Hayashi, M., Ohzeki, H., Shimada, H., Unemoto, T.
    NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli.
    Biochim. Biophys. Acta 1273 : 165-170 (1996). [PMID: 8611590]

[EC created 1972 as EC, transferred 2011 to EC]