EC 1 - Oxidoreductases
EC 1.6 - Acting on NADH or NADPH
EC 1.6.5 - With a quinone or similar compound as acceptor
EC 1.6.5.10 - NADPH dehydrogenase (quinone)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.6.5.10
Names
Accepted name:
NADPH dehydrogenase (quinone)
Other
names:
NADPH oxidase
reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase
NADPH2 dehydrogenase (quinone)
reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase
NADPH2 dehydrogenase (quinone)
Systematic name:
NADPH:(quinone-acceptor) oxidoreductase
Reaction
- NADPH + H+ + a quinone = NADP+ + a quinol
Cofactor
Comments:
A flavoprotein [1,2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3]. Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].
Links to other databases
Gene Ontology:
GO:0008753
CAS Registry Number:
37256-37-4
UniProtKB/Swiss-Prot:
CBR4-2_HUMAN
CBR4_BOVIN
CBR4_HUMAN
CBR4_MOUSE
CBR4_RAT
MDAB_ECO57
MDAB_ECOL6
MDAB_ECOLI
MDAB_HAEIN
References
-
Purification and properties of three separate menadione reductases from hog liver.J. Biol. Chem. 244 : 621-629 (1969). [PMID: 4388793]
-
Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli.Biochim. Biophys. Acta 1035 : 230-236 (1990). [PMID: 2118386]
-
NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli.Biochim. Biophys. Acta 1273 : 165-170 (1996). [PMID: 8611590]
[EC 1.6.5.10 created 1972 as EC 1.6.99.6, transferred 2011 to EC 1.6.5.10]