EC 1.6.2.4 - NADPH—hemoprotein reductase
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IntEnz Enzyme Nomenclature
EC 1.6.2.4
Names
Accepted name:
NADPH—hemoprotein reductase
Other
names:
CPR
FAD-cytochrome c reductase
NADP—cytochrome c reductase
NADP—cytochrome reductase
NADPH-dependent cytochrome c reductase
NADPH:P-450 reductase
NADPH:ferrihemoprotein oxidoreductase
NADPH—cytochrome P-450 oxidoreductase
NADPH—cytochrome c oxidoreductase
NADPH—cytochrome c reductase
NADPH—cytochrome p-450 reductase
NADPH—ferricytochrome c oxidoreductase
NADPH—ferrihemoprotein reductase
TPNH2 cytochrome c reductase
TPNH-cytochrome c reductase
aldehyde reductase (NADPH-dependent)
cytochrome P-450 reductase
cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
ferrihemoprotein P-450 reductase
reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
cytochrome P450 reductase
NADPH—cytochrome P450 reductase
NADPH—cytochrome P450 oxidoreductase
NADPH:P450 reductase
POR
FAD-cytochrome c reductase
NADP—cytochrome c reductase
NADP—cytochrome reductase
NADPH-dependent cytochrome c reductase
NADPH:P-450 reductase
NADPH:ferrihemoprotein oxidoreductase
NADPH—cytochrome P-450 oxidoreductase
NADPH—cytochrome c oxidoreductase
NADPH—cytochrome c reductase
NADPH—cytochrome p-450 reductase
NADPH—ferricytochrome c oxidoreductase
NADPH—ferrihemoprotein reductase
TPNH2 cytochrome c reductase
TPNH-cytochrome c reductase
aldehyde reductase (NADPH-dependent)
cytochrome P-450 reductase
cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
ferrihemoprotein P-450 reductase
reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
cytochrome P450 reductase
NADPH—cytochrome P450 reductase
NADPH—cytochrome P450 oxidoreductase
NADPH:P450 reductase
POR
Systematic name:
NADPH:hemoprotein oxidoreductase
Reaction
- NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Cofactors
Comments:
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
Links to other databases
Gene Ontology:
GO:0003958
CAS Registry Number:
9023-03-4
References
-
The enzymatic reduction of cytochrome c, cytochrome c reductase.J. Biol. Chem. 136 : 747-774 (1940).
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Triphosphopyridine nucleotide-cytochrome c reductase in liver.J. Biol. Chem. 183 : 593-605 (1950).
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Resolution of the cytochrome P-450-containing ω-hydroxylation system of liver microsomes into three components.J. Biol. Chem. 244 : 3714-3721 (1969). [PMID: 4389465]
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Studies on the mechanism of microsomal triphosphopyridine nucleotide-cytochrome c reductase.J. Biol. Chem. 240 : 921-931 (1965).
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Microsomal triphosphopyridine nucleotide-cytochrome c reductase in liver.J. Biol. Chem. 237 : 587-595 (1962). [PMID: 14007123]
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The mechanism of 1- and 2-electron transfers catalyzed by reduced triphosphopyridine nucleotide-cytochrome c reductase.J. Biol. Chem. 240 : 4081-4088 (1965). [PMID: 4378860]
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NADPH-P-450 reductase: Structural and functional comparisons of the eukaryotic and prokaryotic isoforms.Biochimie 77 : 562-572 (1995). [PMID: 8589067]
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Three-dimensional structure of NADPH-cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes.Proc. Natl. Acad. Sci. USA 94 : 8411-8416 (1997). [PMID: 9237990]
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Determination of the redox properties of human NADPH-cytochrome P450 reductase.Biochemistry 40 : 1956-1963 (2001). [PMID: 11329262]
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Electron transfer in human cytochrome P450 reductase.Biochem. Soc. Trans. 31 : 497-501 (2003). [PMID: 12773143]
[EC 1.6.2.4 created 1972, modified 2003]