EC - NAD(P)+ transhydrogenase (Re/Si-specific)

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IntEnz Enzyme Nomenclature


Accepted name:
NAD(P)+ transhydrogenase (Re/Si-specific)
Other names:
NAD transhydrogenase
NAD(P) transhydrogenase
NADH transhydrogenase
NADPH-NAD oxidoreductase
NADPH-NAD transhydrogenase
NADPH:NAD+ transhydrogenase
energy-linked transhydrogenase
nicotinamide adenine dinucleotide (phosphate) transhydrogenase
nicotinamide nucleotide transhydrogenase
pyridine nucleotide transferase
pyridine nucleotide transhydrogenase
NAD(P)+ transhydrogenase (AB-specific)
NADPH:NAD+ oxidoreductase (AB-specific)
Systematic name:
NADPH:NAD+ oxidoreductase (Re/Si-specific)



The enzyme from heart mitochondria is Re-specific with respect to NAD+ and Si-specific with respect to NADP+ (cf. EC NAD(P)+ transhydrogenase (Si-specific)).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00654
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008750
CAS Registry Numbers: 9014-18-0 9072-60-0


  1. Fisher, R.R. and Earle, S.R.
    Membrane-bound pyridine dinucleotide transhydrogenases.
    In: Everse, J., Anderson, B. and You, K. (Eds.) The Pyridine Nucleotide Coenzymes , Academic Press , New York , 1982 , 279-324
  2. You, K.-S.
    Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions.
    CRC Crit. Rev. Biochem. 17 : 313-451 (1985). [PMID: 3157549]

[EC created 1986, modified 2013]