EC 1.5.99.15 - Dihydromethanopterin reductase (acceptor)

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IntEnz Enzyme Nomenclature
EC 1.5.99.15

Names

Accepted name:
dihydromethanopterin reductase (acceptor)
Other name:
DmrX
Systematic name:
5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase

Reaction

Cofactors

Comments:

This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a coenzyme used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0044684
UniProtKB/Swiss-Prot:

References

  1. Wang, S., Tiongson, J., Rasche, M. E.
    Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.
    J. Bacteriol. 196 : 203-209 (2014). [PMID: 23995635]

[EC 1.5.99.15 created 2014]