EC - 6-hydroxypseudooxynicotine dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
6-hydroxypseudooxynicotine dehydrogenase
Systematic name:
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating)




Contains a cytidylyl molybdenum cofactor [3]. The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034909


  1. Freudenberg, W., Konig, K. and Andreesen, J. R.
    Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase.
    FEMS Microbiology Letters 52: 13-18 (1988).
  2. Grether-Beck, S., Igloi, G. L., Pust, S., Schilz, E., Decker, K., Brandsch, R.
    Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans.
    Mol. Microbiol. 13: 929-936 (1994). [PMID: 7815950]
  3. Sachelaru, P., Schiltz, E., Brandsch, R.
    A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans.
    Appl. Environ. Microbiol. 72: 5126-5131 (2006). [PMID: 16820521]

[EC created 2012]