EC - Cytokinin dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
cytokinin dehydrogenase
Other names:
cytokinin oxidase
N6-dimethylallyladenine:(acceptor) oxidoreductase
6-N-dimethylallyladenine:acceptor oxidoreductase
Systematic name:
N6-dimethylallyladenine:acceptor oxidoreductase




A flavoprotein(FAD). Converts zeatin and related cytokinins. Catalyses the oxidation of cytokinins, a family of N6-substituted adenine derivatives that are plant hormones, where the substituent is a dimethylallyl or other prenyl group. Although this activity was previously thought to be catalysed by a hydrogen-peroxide-forming oxidase, this enzyme does not require oxygen for activity and does not form hydrogen peroxide. 2,6-Dichloroindophenol, methylene blue, nitroblue tetrazolium, phenazine methosulfate and Cu(II) in the presence of imidazole can act as acceptors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019139
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Galuszka, P., Frebort, I., Sebela, M., Jacobsen, S. and Pec, P.
    Cytokinin oxidase or dehydrogenase? Mechanism of cytokinin degradation in plants.
    Eur. J. Biochem. 268 : 450-461 (2001). [PMID: 11168382]

[EC created 2001]