EC - Methylenetetrahydromethanopterin dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
methylenetetrahydromethanopterin dehydrogenase
Other names:
5,10-methylenetetrahydromethanopterin dehydrogenase
N5,N10-methylenetetrahydromethanopterin dehydrogenase
Systematic name:
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase



Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 100357-01-5
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Hartzell, P.L., Zvilius, G., Escalante-Semerena, J.C. and Donnelly, M.I.
    Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.
    Biochem. Biophys. Res. Commun. 133: 884-890 (1985). [PMID: 4084309]
  2. te Brömmelstroet, B.W., Geerts, W.J., Keltjens, J.T., van der Drift, C. and Vogels, G.D.
    Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
    Biochim. Biophys. Acta 1079: 293-302 (1991). [PMID: 1911853]

[EC created 1989 as EC, modified 2004, transferred 2014 to EC]