EC - Sarcosine dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
sarcosine dehydrogenase
Other names:
monomethylglycine dehydrogenase
sarcosine N-demethylase
sarcosine:(acceptor) oxidoreductase (demethylating)
Systematic name:
sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)




A flavoprotein (FMN). Tetrahydrofolate is also a substrate, being converted to N5,N10-methylenetetrahydrofolate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008480
CAS Registry Number: 37228-65-2


  1. Frisell, W.R. and MacKenzie, C.G.
    Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
    J. Biol. Chem. 237: 94-98 (1962). [PMID: 13895406]
  2. Hoskins, D.D. and MacKenzie, C.G.
    Solubilization and electron transfer flavoprotein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
    J. Biol. Chem. 236: 177-183 (1961). [PMID: 13716069]
  3. Steenkamp, D. J., Husain, M.
    The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases.
    Biochem. J. 203: 707-715 (1982). [PMID: 6180732]

[EC created 1972 as EC, transferred 2012 to EC]