EC 1 - Oxidoreductases
EC 1.5 - Acting on the CH-NH group of donors
EC 1.5.8 - With a flavin as acceptor
EC 1.5.8.2 - Trimethylamine dehydrogenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.5.8.2
Names
Accepted name:
trimethylamine dehydrogenase
Systematic name:
trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)
Reaction
- trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
Cofactors
Comments:
A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors; phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. Contains FAD and a [4Fe-4S] cluster.
Links to other databases
Gene Ontology:
GO:0050470
CAS Registry Number:
39307-09-0
UniProtKB/Swiss-Prot:
DHTM_METME
References
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The purification and properties of a bacterial trimethylamine dehydrogenase.Biochem. J. 121 : 9P-10P (1971).
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Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis.Biochem. J. 169 : 361-369 (1978). [PMID: 204297]
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The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein.J. Biol. Chem. 270 : 23958-23965 (1995). [PMID: 7592591]
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Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein.J. Biol. Chem. 277 : 8457-8465 (2002). [PMID: 11756429]
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Trimethylamine dehydrogenase and electron transferring flavoprotein.Subcell. Biochem. 35 : 145-181 (2000). [PMID: 11192721]
[EC 1.5.8.2 created 1976 as EC 1.5.99.7, transferred 2002 to EC 1.5.8.2]