EC - Methylenetetrahydrofolate reductase (ferredoxin)

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IntEnz Enzyme Nomenclature


Accepted name:
methylenetetrahydrofolate reductase (ferredoxin)
Other name:
5,10-methylenetetrahydrofolate reductase
Systematic name:
5-methyltetrahydrofolate:ferredoxin oxidoreductase




An iron-sulfur flavoprotein that also contains zinc. The enzyme from Clostridium formicoaceticum catalyses the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate. However, unlike EC, methylenetetrahydrofolate reductase [NAD(P)H], there is no activity with NAD(P)H.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033738


  1. Clark, J.E. and Ljungdahl, L.G.
    Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum.
    J. Biol. Chem. 259: 10845-10849 (1984). [PMID: 6381490]

[EC created 2005]