EC 1.5.5.3 - Hydroxyproline dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.5.5.3

Names

Accepted name:
hydroxyproline dehydrogenase
Other names:
HYPDH
OH-POX
hydroxyproline oxidase
PRODH2 (gene name)
Systematic name:
trans-4-hydroxy-L-proline:quinone oxidoreductase

Reaction

Cofactor

Comments:

A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Cooper, S. K., Pandhare, J., Donald, S. P., Phang, J. M.
    A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.
    J. Biol. Chem. 283: 10485-10492 (2008). [PMID: 18287100]
  2. Summitt, C. B., Johnson, L. C., Jonsson, T. J., Parsonage, D., Holmes, R. P., Lowther, W. T.
    Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
    Biochem. J. 466: 273-281 (2015). [PMID: 25697095]

[EC 1.5.5.3 created 2017]