EC 1.5.4.1 - Pyrimidodiazepine synthase

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IntEnz Enzyme Nomenclature
EC 1.5.4.1

Names

Accepted name:
pyrimidodiazepine synthase
Other names:
PDA synthase
pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing)
pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Systematic name:
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)

Reaction

Comments:

In the reverse direction of reaction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine involved is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004734
CAS Registry Number: 93586-06-2
UniProtKB/Swiss-Prot:

References

  1. Wiederrecht, G.J. and Brown, G.M.
    Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.
    J. Biol. Chem. 259: 14121-14127 (1984). [PMID: 6438092]
  2. Kim, J., Suh, H., Kim, S., Kim, K., Ahn, C., Yim, J.
    Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.
    Biochem. J. 398: 451-460 (2006). [PMID: 16712527]

[EC 1.5.4.1 created 1990, modified 2014]