EC - Saccharopine dehydrogenase (NAD+, L-glutamate-forming)

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IntEnz Enzyme Nomenclature


Accepted name:
saccharopine dehydrogenase (NAD+, L-glutamate-forming)
Other names:
NAD+ oxidoreductase (L-2-aminoadipic-δ-semialdehyde and glutamate forming)
aminoadipic semialdehyde synthase
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)
saccharopin dehydrogenase
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
Systematic name:
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)



The activitites of this enzyme along with EC, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047131
CAS Registry Number: 37256-26-1


  1. Hutzler, J. and Dancis, J.
    Conversion of lysine to saccharopine by human tissues.
    Biochim. Biophys. Acta 158 : 62-69 (1968). [PMID: 4385118]
  2. Markovitz, P.J., Chuang, D.T. and Cox, R.P.
    Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
    J. Biol. Chem. 259 : 11643-11646 (1984). [PMID: 6434529]

[EC created 1972, modified 2011]