EC - Saccharopine dehydrogenase (NADP+, L-lysine-forming)

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IntEnz Enzyme Nomenclature


Accepted name:
saccharopine dehydrogenase (NADP+, L-lysine-forming)
Other names:
L-lysine-α-ketoglutarate reductase
lysine-2-oxoglutarate reductase
lysine-ketoglutarate reductase
lysine:α-ketoglutarate:TPNH oxidoreductase (ε-N-[gultaryl-2]-L-lysine forming)
saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Systematic name:
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047130
CAS Registry Number: 9031-19-0


  1. Hutzler, J. and Dancis, J.
    Conversion of lysine to saccharopine by human tissues.
    Biochim. Biophys. Acta 158: 62-69 (1968). [PMID: 4385118]
  2. Markovitz, P.J., Chuang, D.T. and Cox, R.P.
    Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
    J. Biol. Chem. 259: 11643-11646 (1984). [PMID: 6434529]

[EC created 1972]