EC - Staphylopine dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
staphylopine dehydrogenase
Other names:
cntM (gene name)
staphylopine synthase
Systematic name:
staphylopine:NADP+ oxidoreductase [(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate]-forming



The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Ghssein, G., Brutesco, C., Ouerdane, L., Fojcik, C., Izaute, A., Wang, S., Hajjar, C., Lobinski, R., Lemaire, D., Richaud, P., Voulhoux, R., Espaillat, A., Cava, F., Pignol, D., Borezee-Durant, E., Arnoux, P.
    Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
    Science 352: 1105-1109 (2016). [PMID: 27230378]
  2. McFarlane, J. S., Davis, C. L., Lamb, A. L.
    Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase.
    J. Biol. Chem. 293: 8009-8019 (2018). [PMID: 29618515]

[EC created 2018]