EC 1.5.1.50 - Dihydromonapterin reductase

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IntEnz Enzyme Nomenclature
EC 1.5.1.50

Names

Accepted name:
dihydromonapterin reductase
Other names:
FolM
H2-MPt reductase
Systematic name:
5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase

Reaction

Comments:

The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). The enzyme has no activity with NADH.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Pribat, A., Blaby, I. K., Lara-Nunez, A., Gregory, J. F., de Crecy-Lagard, V., Hanson, A. D.
    FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
    J. Bacteriol. 192 : 475-482 (2010). [PMID: 19897652]

[EC 1.5.1.50 created 2015]