EC 1.5.1.43 - Carboxynorspermidine synthase

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IntEnz Enzyme Nomenclature
EC 1.5.1.43

Names

Accepted name:
carboxynorspermidine synthase
Other names:
carboxynorspermidine dehydrogenase
carboxyspermidine dehydrogenase
CASDH
CANSDH
VC1624 (gene name)
Systematic name:
carboxynorspermidine:NADP+ oxidoreductase

Reactions

Comments:

The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Nakao, H., Shinoda, S., Yamamoto, S.
    Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus.
    J. Gen. Microbiol. 137: 1737-1742 (1991). [PMID: 1955861]
  2. Lee, J., Sperandio, V., Frantz, D. E., Longgood, J., Camilli, A., Phillips, M. A., Michael, A. J.
    An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
    J. Biol. Chem. 284: 9899-9907 (2009). [PMID: 19196710]
  3. Hanfrey, C. C., Pearson, B. M., Hazeldine, S., Lee, J., Gaskin, D. J., Woster, P. M., Phillips, M. A., Michael, A. J.
    Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
    J. Biol. Chem. 286: 43301-43312 (2011). [PMID: 22025614]

[EC 1.5.1.43 created 2012]