EC 1.5.1.39 - FMN reductase [NAD(P)H]

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IntEnz Enzyme Nomenclature
EC 1.5.1.39

Names

Accepted name:
FMN reductase [NAD(P)H]
Other name:
FRG
Systematic name:
FMNH2:NAD(P)+ oxidoreductase

Reaction

Cofactor

Comments:

Contains FMN [3]. The enzyme can utilize NADH and NADPH with similar reaction rates. Different from EC 1.5.1.42, FMN reductase (NADH) and EC 1.5.1.38, FMN reductase (NADPH). The luminescent bacterium Vibrio harveyi possesses all three enzymes [2], while the bacterium Aliivibrio fischeri contains only this non-specific type [3]. Also reduces riboflavin and FAD, but more slowly.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052874 , GO:0052873 , GO:0008752
UniProtKB/Swiss-Prot:

References

  1. Tu, S. C., Becvar, J. E., Hastings, J. W.
    Kinetic studies on the mechanism of bacterial NAD(P)H:flavin oxidoreductase.
    Arch. Biochem. Biophys. 193 : 110-116 (1979). [PMID: 222213]
  2. Watanabe, H., Hastings, J. W.
    Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase.
    Mol. Cell. Biochem. 44 : 181-187 (1982). [PMID: 6981058]
  3. Tang, C. K., Jeffers, C. E., Nichols, J. C., Tu, S. C.
    Flavin specificity and subunit interaction of Vibrio fischeri general NAD(P)H-flavin oxidoreductase FRG/FRase I.
    Arch. Biochem. Biophys. 392 : 110-116 (2001). [PMID: 11469801]

[EC 1.5.1.39 created 2011]