EC - Flavin reductase (NADH)

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IntEnz Enzyme Nomenclature


Accepted name:
flavin reductase (NADH)
Other names:
NADH-dependent flavin reductase
flavin:NADH oxidoreductase
Systematic name:
flavin:NAD+ oxidoreductase



The enzyme from Escherichia coli W catalyses the reduction of free flavins by NADH. The enzyme has similar affinity to FAD, FMN and riboflavin. Activity with NADPH is more than 2 orders of magnitude lower than activity with NADH.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036382
UniProtKB/Swiss-Prot: (16) [show] [UniProt]


  1. Galan, B., Diaz, E., Prieto, M. A., Garcia, J. L.
    Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new flavin:NAD(P)H reductase subfamily.
    J. Bacteriol. 182 : 627-636 (2000). [PMID: 10633095]

[EC created 2011]