EC - Flavin reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
flavin reductase (NADPH)
Other names:
FMN reductase (NADPH)
NADPH-dependent FMN reductase
NADPH-specific FMN reductase
NADPH:flavin oxidoreductase
NADPH2 dehydrogenase (flavin)
NADPH2:riboflavin oxidoreductase
flavin mononucleotide reductase
flavine mononucleotide reductase
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase
riboflavin mononucleotide reductase
riboflavine mononucleotide reductase
NADPH-FMN reductase
NADPH dehydrogenase (flavin)
NADPH:riboflavin oxidoreductase
NADPH-flavin reductase
Systematic name:
reduced-riboflavin:NADP+ oxidoreductase



The enzyme from Entamoeba histolytica reduces riboflavin and galactoflavin, and, more slowly, FMN and FAD. NADH is oxidized more slowly than NADPH.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0042602
CAS Registry Number: 56626-29-0


  1. Lo, H.-S. and Reeves, R.E.
    Purification and properties of NADPH:flavin oxidoreductase from Entamoeba histolytica.
    Mol. Biochem. Parasitol. 2 : 23-30 (1980). [PMID: 6258069]
  2. Yubisui, T., Tamura, M. and Takeshita, M.
    Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
    Biochem. Int. 15 : 1-8 (1987). [PMID: 3453680]

[EC created 1982 as EC, transferred 2002 to EC, modified 2011]