EC - Pyrroline-5-carboxylate reductase

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IntEnz Enzyme Nomenclature


Accepted name:
pyrroline-5-carboxylate reductase
Other names:
1-pyrroline-5-carboxylate reductase
L-proline oxidase
L-proline-NAD(P)+ 5-oxidoreductase
NADPH-L1-pyrroline carboxylic acid reductase
proline oxidase
Systematic name:
L-proline:NAD(P)+ 5-oxidoreductase



Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00451
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004735
CAS Registry Number: 9029-17-8
UniProtKB/Swiss-Prot: (66) [show] [UniProt]


  1. Adams, E. and Goldstone, A.
    Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Δ1-pyrroline-3-hydroxy-5-carboxylate.
    J. Biol. Chem. 235 : 3499-3503 (1960).
  2. Meister, A., Radhakrishnan, A.N. and Buckley, S.D.
    Enzymatic synthesis of L-pipecolic acid and L-proline.
    J. Biol. Chem. 229 : 789-800 (1957).
  3. Smith, M.E. and Greenberg, D.M.
    Characterization of an enzyme reducing pyrroline-5-carboxylate to proline.
    Nature (Lond.) 177 : 1130 (1956).
  4. Yura, T. and Vogel, H.J.
    Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties.
    J. Biol. Chem. 234 : 335-338 (1959).

[EC created 1961]